PI: Ted Cohen
TREAT TB: Technology, Research, and Technical Assistant for Tuberculosis (USAID). The goals of this project include 1) fully characterizing TB transmission patterns with the Republic of Moldova; 2) better understanding the relative contribution of acquired and transmitted resistance to the MDR-TB epidemic in Moldova; and 3) understanding how whole genome sequencing (WGS) can be used to inform the rational targeting of TB interventions and to estimate the costs associated with scale up of programmatic WGS.
Funder: Vital Strategies, Inc. via United States Agency for International Development (USAID)
Co-PIs: Ted Cohen and Joshua Salomon, Stanford University
This project aims to provide a rigorous, systematic and comprehensive examination of the potential impact and value for money associated with more targeted approaches to preventative therapy and active TB-case findings in nine sub-Saharan African countries with high TB and HIV burdens.
PI: Dr. Shen
Funder: Shanghai Center for Disease Control (CDC)
Strategies for TB control in prisons
PI: Jason Andrews, Stanford University
This project aims to combine genomic, epidemiological and spatial information to better understand the transmission dynamics of TB in Brazilian prisons and to examine possible spillover from prisons in the surrounding communities.
TB modeling and analysis consortium (TB MAC)
PI: Richard White
The overall aim of TB MAC is to improve global TB care and control by coordinating and promoting mathematical modeling and other qualitative research relevant to support evidence-based policy making and implementation. The objectives include: 1) reviewing high-priority research questions concerning TB care and control that require mathematical modeling and other quantitative research; 2) reviewing data, information and expertise to achieve consensus on current knowledge, knowledge gaps, methodological standards and current best practices for TB care and care, control and decision making; 3) disseminate information and tools to key stakeholders, including TB care and control programs and donors.
Funder: Bill and Melinda Gates Foundation
The role of casual contact and migration in XDR TB transmission in South Africa: a geospatial, genomic and social network study.
PI: Neil Gandhi, Emory University
The goal of this study is to conduct intensive epidemiological, geospatial and genomic analysis of XDR TB cases within and outside selected hotspots in South Africa.
PI: Josh Salomon, Stanford University
The mission of the Prevention Policy modeling lab is to support the U.S. Center for Disease Control (CDC) to improve prevention effectiveness at national, state and local levels, by supplying mathematical and economic modeling that is highly salient, flexible, swift and scientifically rigorous. We are developing and applying models that improve the ability to evaluate policy options, allocate resources, understand impact of program investments and maximize value for money. In collaboration with CDC partners, we are identifying and pursuing priorities for modeling and analyses relating to costs, burden of illness, cost effectiveness, cost benefits, population impact and resource allocation in all five program areas.
Funder: U.S. CDC